Sputnik V
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Sputnik V Vaccine is the Russian vaccine for the virus causing the COVID-19 pandemic. The COVID-19 vaccine can help safeguard individuals and manage the pandemic triggered by SARS-CoV-2. Many scientists and countries have created vaccines and are still working to create an even more effective vaccination dose.

Sputnik V is the globe’s first certified vaccine dependent on a human adenovirus vector platform that has been thoroughly researched. It is legal in 70 countries with a total population of 4 billion people. The vaccine is given the name taking inspiration from the first Soviet space satellite, Sputnik-1, which revitalized space exploration all around the planet in 1957, establishing that Sputnik moment for international society.

The Sputnik V Vaccine (Gam-COVID-Vac) is one of three COVID-19 vaccines worldwide with more than 90% effectiveness and was the planet’s first authorized coronavirus vaccine. Over 68 countries, including India, are dispensing it to their citizens, facilitating the fight versus COVID-19. Sputnik Vaccine is available to 40% of the world’s population, or more than 300 crores (3 billion) individuals.

The Gamaleya National Research Center produced the Sputnik V Vaccine for Epidemiology and Microbiology of the Russian Federation’s Ministry of Health in Moscow, Russia. The Russian Direct Investment Fund (RDIF) will manufacture Gam-COVID-Vac supplies for the global market through its foreign partners in India, South Korea, and other nations.

The information obtained from the trials shows that Sputnik V holds its protective properties against emerging coronavirus strains. The decrease in the viral neutralizing capacity of Sputnik V against a range of strains was distinctly less compared to other vaccine manufacturers. Sputnik V is effective against most emerging strains of coronavirus. The vaccine produces protective neutralizing antibody titers against new strains, including alpha, beta, gamma, delta B.1.617.2 and B.1.617.3 (first identified in India), and mutated variants.

Mechanism of the Sputnik V Vaccine

The Sputnik V (Gam-COVID-Vac) uses two distinct adenoviral vectors to produce the SARS-CoV-2 spike protein gene: Adenovirus 26 (Ad26) and Adenovirus 5 (Ad5). Combining two different serotypes is a novel strategy that provides long-lasting protection while also strengthening the immune system reaction. The carrier viruses have been altered to no longer infect cells; instead, they enter cells, express the spike protein, and end. High sensitivity detected the expression of a few viral genes but at a significantly reduced level.

The vaccine-infected cells are ultimately killed by the immunity they were intended to trigger. Despite their inability to reproduce, the cells stimulate the immunity sensors to ensure a strong natural immune system. Here, recombinant adenoviruses (rAD) have been frequently utilized as vaccination vectors.

Efficacy of the Sputnik V Vaccine

The studies and evaluation of around 20 thousand people who received the two doses showed that the vaccine was 91.6% effective. After experimental testing in two phases, the Lancet journal reported worldwide peer-reviewed efficacy data.

As per the latest data for more than 38 lakh people in Russia who were vaccinated with two doses, the Sputnik V COVID-19 vaccine has an approximately 98% efficiency rate.

In addition, the Ministry of Health of the United Arab Emirates provided statistics on 81,000 people who received two doses of the vaccine. The report suggested a 97.8% efficacy in avoiding symptomatic COVID-19 infection and a 100% efficacy in avoiding severe COVID-19 infection. The Sputnik V Vaccine demonstrated excellent safety, immunogenicity, and effectiveness in Phase 3 clinical studies.

The trial results were as follows:

  • In the trial, the vaccinated set of people produced a humoral immune reaction in 98% of cases and a cellular immune reaction in 100% of cases.
  • For the older population, the vaccine had a 91.8% effectiveness rate.
  • People produced virus neutralizing antibodies were 1.3 to 1.5 times greater than those seen in people cured from COVID-19 after vaccination.

Dosage and Schedule of the Sputnik V Vaccine

Several adults or people over the age of 18 have been given the Sputnik V vaccination, a two-dose schedule vaccine. After 21 days / 3 weeks from the first dosage, the second dose must be administered.

The Sputnik V Vaccine (Gam-COVID-Vac) employs two very safe human adenoviruses as vectors: Adenovirus 26 (Ad26) and Adenovirus 5 (Ad5) (Ad5). Treatments and vaccines based on human adenoviruses have been extensively employed for more than fifty years.

Cost of the Sputnik V Vaccine

On 21 June 2021, a new vaccination policy was introduced, announcing that every Indian citizen above 18 will get a free vaccine. The two-dose Sputnik V vaccine is now being distributed free of charge to the common people in INDIA by the central government. The government allocates vaccines to states and union territories depending on infection load, population, and inoculation status.

The central government purchases 75% of vaccinations from an Indian producer and redistributes them to the states and UTs. The remaining 25% of vaccinations can be obtained from the maker by private hospitals. According to the guidelines, private hospitals may charge up to INR 150 per dosage in service costs. The state government regulates these prices.

The highest selling price for every dose of Sputnik V Vaccine, including all taxes, is Rupees 995. The first dosage contains 0.5 ml rAD26 (recombinant adenovirus serotype 26 particles). In contrast, the second dose contains 0.5 ml rAD5. The vaccine rate for every dosage of the Sputnik V Vaccine in India should be around Rupees 1,145, including all the taxes.

Administration of the Sputnik V Vaccine

The Drugs Controller General of India (DCGI) approved the limited emergency usage of “The Sputnik V vaccine” in India in April 2021. Dr Reddy’s Laboratories Limited (DRL), a Hyderabad-based pharmaceutical firm, introduced Russia’s Sputnik-V vaccine, a two combination vector vaccine, in the country on 14 May 2021. People can visit the vaccination centres straightaway and get immunized or reserve a Sputnik V Vaccine appointment using online Cowin registration.

Dr Reddy Labs has agreed to supply 125 million vaccine vials through the Russia Direct Investment Fund (RDIF). Arrangements are also in the works with Indian pharmaceutical companies to manufacture 850 million dosages of the Sputnik V vaccine estimated by the end of this year. Sputnik V was started to be given to the citizens around the end of April 2021. Moreover, according to reports, more than ten crore doses of the Sputnik V vaccine are expected to be imported for emergency usage in the nation in the next half-year. India, the world’s largest vaccine manufacturer, has emerged as one of the leading manufacturers of the Sputnik V jab beyond Russia.

Sputnik V is a unique vaccine that employs two distinct vectors to deliver both doses. The use of two distinct adenovirus vectors provides a more powerful immune system response. The two doses make this vaccine more effective against coronavirus mutations. Unlike other vaccinations, it has a storing temperature range of 2 to 8 degrees Celsius. The vaccine doses may be preserved in a standard freezer.

Side Effects of the Sputnik V Vaccine

The Sputnik V vaccine has good safety outcomes and proved efficient against the novel coronavirus strains. The S Protein of SARS-CoV-2 elicited a specific immune response in all the participants.

Sputnik V Vaccine has been linked to the following minor side effects:

  • At the injection spot, you may experience pain, irritation, or inflammation.
  • Asthenia (unusual physical tiredness caused by a lack of strength)
  • Exhaustion (feeling tired)
  • Allergic reaction
  • Muscles and joint discomfort
  • Throat infection and coughing
  • a stuffy nose
  • Shivers and Fever
  • Throwing up and Nausea
  • Diarrhoea
  • Dizziness

In the majority of cases, side effects subside within a day or two. But still, if any side effects last more than two days, consult the vaccination facility or your doctor and begin taking medicines to treat them. As per the trials, there were no indications of significant side effects or allergic reactions after vaccination. Some people have reported no side effects, and everyone’s response to the vaccination is mostly favourable. It is normal if there are no negative side effects.


Sputnik V, developed in Russia, employs a weaker virus to inject tiny amounts of a pathogen and induce an immune reaction. Sputnik V is a vaccine with two components. The initial vaccine induces humoral cellular immunity, while a second vaccine induces the formation of memory cells. According to a peer-reviewed paper, the phase 3 trial of the vaccine demonstrated 91.6% effectiveness against COVID-19. It was adequately handled in a broad population. Sputnik V is estimated to cost approximately Rupees 948 per dosage in India. With 5% GST, the price per dosage might rise to Rupees 995. So, two injections will cost between Rupees 1,990 and Rupees 2,000 per individual.

For more information about the Sputnik V Vaccine, visit the e-Gurukul app to know the latest updates!

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